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All GSMS courses

Only GSMS PhD students (including BCN PhD students) can participate in these courses. Use your P-number to register (ask your Personnel Office).

For registration please go to Upcoming courses.

Course: Blood-material interactions

Manufacturers of medical devices want their devices to be safe and biocompatible. It has

been recognized that blood compatibility of materials is of pivotal importance for the

compliance of blood-contacting devices. Blood in itself can be considered a very

complex and intriguing organ with extensive interaction with all parts of the human body.

The components of blood and some of the regulatory pathways will be presented. The

implications for the scope of testing will also be discussed. Five testing categories have

been outlined in the recently harmonized and published standard EN ISO 10993 – Part 4:

‘Selection of tests for interactions with blood’. Aspects include materials characterization

of medical devices and materials and biomaterials; in-vitro tests for blood compatibility;

sample analyses from in-vivo studies; and batch release testing for finished products.

Moreover, test conditions must consider the clinical use of the device, which implies

testing in circulating blood. Finally, testing methods for studying blood-material

interactions will be presented (ELISA, RIA; EIA, colorimetric methods; enzymatic assays;

clotting assays; platelet functionality; antibody-binding studies; and fluorometric and

luminometric methods).

EC (without exam)



  • Dr. Theo G. van Kooten, UMCG - BME

Course coordinator

  • Dr. Theo G. van Kooten, UMCG - BME



Target Groups

  • PhD students

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